Formulation and Characterization of Self-Microemulsifying Drug Delivery System of Tacrolimus

Abstract
 The present investigation aimed to formulate a liquid self-microemulsifying drug delivery system (SMEDDS) of tacrolimus enhance its oral bioavailability by improving dispersibility and dissolution rate. Four SMEDDS were prepared using maisine CC as oil phase, labrasol ALF surfactant transcutol HP co-surfactant based on the solubility studies in these components. phase behavior components area microemulsion evaluated pseudoternary diagrams. formulations also assessed for thermodynamic stability, robustness dilution, self-emulsification time, content, globule size polydispersity index. exhibited improved release compared pure powder. From this study, it was concluded that composition 10% CC, 67.5% 22.5% produced with good stability enhanced in-vitro profiles All which supports use self-micro emulsifying systems promising approach improve solubility, poorly soluble drugs like tacrolimus.